TY - JOUR
T1 - Neuroimaging predictors of response to cognitive remediation and social skills training
T2 - A pilot study in veterans with schizophrenia
AU - McClure, Margaret M.
AU - Graff, Fiona S.
AU - Triebwasser, Joseph
AU - Perez-Rodriguez, M. Mercedes
AU - Rosell, Daniel R.
AU - Szeszko, Philip R.
AU - Chu, King Wai
AU - New, Antonia S.
AU - Siever, Larry J.
AU - Hazlett, Erin A.
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/11/30
Y1 - 2019/11/30
N2 - Neuroimaging may predict response to cognitive remediation therapy and social skills training (CRT + SST) in schizophrenia. Identifying biological predictors of response is crucial for treatment decision making given not all patients respond to such interventions. Nineteen veterans with schizophrenia enrolled in an 8-week trial of CRT + SST. Ten participants completed diffusion tensor imaging (DTI) at baseline. Baseline fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and overall average FA predicted improvements in visual-spatial working memory, and social cognition, respectively. Neuroimaging may be useful in identifying therapeutic targets in schizophrenia.
AB - Neuroimaging may predict response to cognitive remediation therapy and social skills training (CRT + SST) in schizophrenia. Identifying biological predictors of response is crucial for treatment decision making given not all patients respond to such interventions. Nineteen veterans with schizophrenia enrolled in an 8-week trial of CRT + SST. Ten participants completed diffusion tensor imaging (DTI) at baseline. Baseline fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and overall average FA predicted improvements in visual-spatial working memory, and social cognition, respectively. Neuroimaging may be useful in identifying therapeutic targets in schizophrenia.
KW - Cognitive remediation
KW - Diffusion tensor imaging
KW - Schizophrenia
KW - Social skills training
UR - https://www.scopus.com/pages/publications/85073733263
UR - https://www.scopus.com/pages/publications/85073733263#tab=citedBy
U2 - 10.1016/j.pscychresns.2019.110988
DO - 10.1016/j.pscychresns.2019.110988
M3 - Article
C2 - 31655369
AN - SCOPUS:85073733263
SN - 0925-4927
VL - 293
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
M1 - 110988
ER -