Carbon nanotube-based electrospun nanofibrous scaffolds for characterization of biological macromolecules

Maeve O’Connell; Matthew Manduca; Isaac Macwan

doi:10.1557/s43579-025-00758-1

Carbon nanotube-based electrospun nanofibrous scaffolds for characterization of biological macromolecules

Maeve O’Connell
, Matthew Manduca
, Isaac Macwan

Fairfield University

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigates the incorporation of bacteriorhodopsin (bR) into PVA-MWNT nanofibrous scaffolds for biosensing applications. PVA-MWNT dispersions were synthesized, and scaffolds were created using electrospinning. The scaffolds were imaged using an SEM and characterized using electrochemical impedance (EIS), which indicated that the presence of bR enhanced the conductivity of the scaffolds, likely by forming conduction pathways through the nanofibers. SEM analysis suggested morphological changes in bR-containing fragments during electrospinning, as they did not align with their control structure observed via AFM. Finite element analysis investigated the diffusion behavior of bR within the scaffold, further supporting its role in conductivity enhancement.

Original language	English
Journal	MRS Communications
DOIs	https://doi.org/10.1557/s43579-025-00758-1
State	Accepted/In press - 2025

ASJC Scopus Subject Areas

General Materials Science

Keywords

Biomaterial
C
Nanoscale fiber
Nanostructure
Polymer
Sensor

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10.1557/s43579-025-00758-1

https://digitalcommons.fairfield.edu/engineering-facultypubs/326/

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title = "Carbon nanotube-based electrospun nanofibrous scaffolds for characterization of biological macromolecules",

abstract = "This study investigates the incorporation of bacteriorhodopsin (bR) into PVA-MWNT nanofibrous scaffolds for biosensing applications. PVA-MWNT dispersions were synthesized, and scaffolds were created using electrospinning. The scaffolds were imaged using an SEM and characterized using electrochemical impedance (EIS), which indicated that the presence of bR enhanced the conductivity of the scaffolds, likely by forming conduction pathways through the nanofibers. SEM analysis suggested morphological changes in bR-containing fragments during electrospinning, as they did not align with their control structure observed via AFM. Finite element analysis investigated the diffusion behavior of bR within the scaffold, further supporting its role in conductivity enhancement. ",

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T1 - Carbon nanotube-based electrospun nanofibrous scaffolds for characterization of biological macromolecules

AU - O’Connell, Maeve

AU - Manduca, Matthew

AU - Macwan, Isaac

N1 - Publisher Copyright: © The Author(s), under exclusive licence to The Materials Research Society 2025.

PY - 2025

Y1 - 2025

N2 - This study investigates the incorporation of bacteriorhodopsin (bR) into PVA-MWNT nanofibrous scaffolds for biosensing applications. PVA-MWNT dispersions were synthesized, and scaffolds were created using electrospinning. The scaffolds were imaged using an SEM and characterized using electrochemical impedance (EIS), which indicated that the presence of bR enhanced the conductivity of the scaffolds, likely by forming conduction pathways through the nanofibers. SEM analysis suggested morphological changes in bR-containing fragments during electrospinning, as they did not align with their control structure observed via AFM. Finite element analysis investigated the diffusion behavior of bR within the scaffold, further supporting its role in conductivity enhancement.

AB - This study investigates the incorporation of bacteriorhodopsin (bR) into PVA-MWNT nanofibrous scaffolds for biosensing applications. PVA-MWNT dispersions were synthesized, and scaffolds were created using electrospinning. The scaffolds were imaged using an SEM and characterized using electrochemical impedance (EIS), which indicated that the presence of bR enhanced the conductivity of the scaffolds, likely by forming conduction pathways through the nanofibers. SEM analysis suggested morphological changes in bR-containing fragments during electrospinning, as they did not align with their control structure observed via AFM. Finite element analysis investigated the diffusion behavior of bR within the scaffold, further supporting its role in conductivity enhancement.

KW - Biomaterial

KW - C

KW - Nanoscale fiber

KW - Nanostructure

KW - Polymer

KW - Sensor

UR - https://www.scopus.com/pages/publications/105007855258

UR - https://www.scopus.com/pages/publications/105007855258#tab=citedBy

U2 - 10.1557/s43579-025-00758-1

DO - 10.1557/s43579-025-00758-1

M3 - Article

AN - SCOPUS:105007855258

SN - 2159-6859

JO - MRS Communications

JF - MRS Communications

ER -

Carbon nanotube-based electrospun nanofibrous scaffolds for characterization of biological macromolecules

Abstract

ASJC Scopus Subject Areas

Keywords

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